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That means that most SARMs are largely untested and remain mostly a mystery when it comes to not only their short term effects but what impacts they can have on long term health. Most SARMs have not even undergone animal studies, so when it comes to their use in humans we are essentially looking at unapproved and untested substances which have never undergone the rigorous testing and trials that other drugs have in the past ‘ including even steroids. This means that the possible side effects of SARMs, while many are now becoming more apparent as more people give these compounds a try, are still not fully understood and it could take many years or even decades to gain an insight of the long term effects caused by SARMs by people who are heavily using them today. Let’s look at the potential side effects of a SARM cycle that are known about: Increased risk of heart attack and stroke. This is a risk factor often listed by regulatory authorities, even though there is little real world evidence in humans to really back this up yet. We know these are risk factors for heavy steroid users and that may also be the case for heavy SARM use in the long term ‘ once again, maintaining sensible dosages of your chosen SARM compounds is key to reducing all side effect risks and minimizing long term health effects. Blind spots and reduced low light vision have shown to be a problem with some SARMs, with Andarine S4 clinical trials in humans resulting in visual changes being one of the most concerns. So while this is not a side effect with all SARMs it is one to watch out for and another area where research is not adequate enough yet for us to know whether other SARMs are a risk to eye health. Some SARMs are thought to potentially worsen your cholesterol health by reducing the good cholesterol type, HDL. This can bring about the potential risk of cardiovascular disease. The true effects of SARMs on cholesterol are still not fully understood with no long term data being available, especially with the off-label use of these compounds among bodybuilders and athletes, and some trials have even found that one SARM in Ostarine resulted in decreased cholesterol levels in trial subjects. In any case it’s wise to maintain a cholesterol friendly diet low in saturated fats and high in healthy omega-3 fatty acids both while you’re using SARMs and when you’re having a break. While not yet known whether SARMs can directly lead to cancer formation in humans, at least one SARM (Cardarine) was terminated from development by the pharmaceutical company GlaxoSmithKline because of severe toxicities including the development of multiple types of cancers in mice was established during long term studies. SARMs are thought to pose a high risk to the liver due to toxicity. An FDA notice in 2017 listed liver damage as one of its primary concerns about the use of SARMs in bodybuilding products. There is still a lot of debate among enthusiasts about whether SARMs are liver toxic, since the make up of their chemical structure theoretically suggests they are not, but the FDA warning and other evidence suggests that liver damage is indeed a risk of SARMs use, even if not as prominent as that which comes with some oral anabolic steroids which can be severely toxic to the liver. So we can see that SARMs are certainly not without their side effects risks, and when used at higher dosages that are more likely by performance athletes, it’s even possible to experience similar or the same side effects as anabolic steroids. While there is still so much still not known about SARMs, it’s an almost certainty that the more SARMs you take, the higher the dosage, and the longer period of time you keep taking them, the inevitability of side effects is virtually impossible to avoid. Because the very few human studies done so far with SARMs have been completed using medical doses which are far lower than athletes use, the side effects at higher doses are not going to be understood fully for some time, mod grf (1-29) (cjc-1295 no dac) 2 mg peptides. SARMs Results: What Should I Expect? Just as with anabolic steroids, different results can be expected with the use of different SARMs. We know some are more useful for cutting and burning fat while others excel at helping you bulk up and gain strength. Users of some SARMs at performance enhancing dosages can expect to see noticeable increases in muscle mass and strength and these will be quality muscle gains because SARMs and the other similar compounds described in this guide don’t cause water retention which can mask so much of your gains on steroids; for users of SARMs this is one of the biggest benefits and most appealing advantages over anabolic steroids. Losing fat is another results you can expect with many SARMs, especially the ones that have been developed to address obesity where they are able to promote the metabolism and burning of stored fat, without putting the body in a catabolic state where you lose muscle tissue. Other SARMs will boost your endurance and your ability to fight off fatigue and muscle soreness, and these are the SARMs that are especially valued by endurance athletes.
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