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Patients should be reevaluated monthly and the dosage adjusted based on reductions of growth hormone or clinical response. The usual optimal therapeutic dosage range of Parlodel varies from 20-30 mg/day in most patients. The maximal dosage should not exceed 100 mg/day. Patients treated with pituitary irradiation should be withdrawn from Parlodel therapy on a yearly basis to assess both the clinical effects of radiation on the disease process as well as the effects of Parlodel therapy. Usually a 4 to 8 week withdrawal period is adequate for this purpose. Recurrence of the signs/symptoms or increases in growth hormone indicate the disease process is still active and further courses of Parlodel should be considered. The basic principle of Parlodel therapy is to initiate treatment at a low dosage and, on an individual basis, increase the daily dosage slowly until a maximum therapeutic response is achieved. The dosage of levodopa during this introductory period should be maintained, if possible. The initial dose of Parlodel is one ? of a 2? mg SnapTabs tablet twice daily with meals. Assessments are advised at 2-week intervals during dosage titration to ensure that the lowest dosage producing an optimal therapeutic response is not exceeded. If necessary, the dosage may be increased every 14 to 28 days by 2? mg/day with meals. Should it be advisable to reduce the dosage of levodopa because of adverse reactions, the daily dosage of Parlodel, if increased, should be accomplished gradually in small (2? mg) increments. The safety of Parlodel has not been demonstrated in dosages exceeding 100 mg/day. How is Parlodel Supplied. Parlodel (bromocriptine mesylate) SnapTabs. Parlodel is available in bottle containing 30 and 100 tablets of 2 ? mg, each bottle contains a desiccant. Round, off-white, bevelled-edge SnapTabs, each containing 2? mg bromocriptine (as the mesylate). Engraved ‘Parlodel 2?’ on one side and ‘017’ on the scored side. Complies with USP dissolution test 1. Packages of 100”””””””””NDC 30698-202-01. Parlodel (bromocriptine mesylate) Capsules. Caramel and white capsules, each containing 5 mg bromocriptine (as the mesylate). Imprinted in red ink ‘Parlodel 5 mg’ on one half and ‘102’ on other half. Packages of 100”””””””””NDC 30698-201-01, steroids for building muscle uk. Store at 68? to 77?F (20? to 25?C); excursions permitted to 59? to 86?F (15? to 30?C) [See USP Controlled Room Temperature].
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